分享一篇发表在Cell Chemical Biology上的文章，题目为“Structural and mechanistic analysis of covalent ligands targeti ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260218/1771399011303937.png)
前沿动态
前沿动态![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260215/1771121483161704.jpg)
原创知识Nature | 解锁调控CRBN功能的隐秘变构位点
分享一篇发表在Nature上的文章，题目为“Identification of an allosteric site on the E3 ligase adapter cereblon”。通讯作者分别 ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260215/1771121178757716.png)
行业文章. Am. Chem. Soc. | 蛋白质中任意目标位点的 ...
分享一篇发表在JACS上的文章，题目为“Rapid and High-Yielding Disulfide Bioconjugation at Any Desired Site in Proteins ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260213/1770964604583255.jpg)
前沿动态Anal. Chem. | 鉴定儿茶酚衍生物相互作用组
分享一篇发表在Analytical Chemistry上的文章，题目为“Nonmodified Strategy Enabled Proteome-Wide Mapping of Catechol D ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260213/1770964300701974.png)
原创知识Nat. Commun. | 序列和构象的联合优化实现蛋白质 ...
推荐一篇发布在Nature Communications上的文章，文章标题“Stable de novo protein design via joint conformational landsca ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260213/1770963339824994.jpg)
前沿动态ACS Chem. Biol. | 棕榈酰化修饰率的定量化学 ...
分享一篇发表在ACS Chemical Biology上的文章：A Chemical Proteomics Method to Quantify Cysteine S-Acylation，通讯作者是波 ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260213/1770963633962358.png)
行业文章Nat. Commun. | 序列和构象的联合优化实现蛋白质 ...
推荐一篇发布在Nature Communications上的文章，文章标题“Stable de novo protein design via joint conformational landsca ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260213/1770962993482691.jpg)
原创知识Nat. Chem. | “借力打力”：通过伪天然产物加速I ...
介绍一篇刚刚发表在Nature chemistry上的文章，题目为Monovalent pseudo-natural products supercharge degradation of IDO1 ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260213/1770962604363536.jpg)
行业文章J. Am. Chem. Soc. | 通过末端偶联实现肽段 ...
分享一篇发表在JACS上的文章，标题为“Terminal Conjugation Enables Nanopore Sequencing of Peptides”，通讯作者为来自荷兰代尔夫特理工大学的 ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260211/1770793614641362.jpg)
前沿动态J. Am. Chem. Soc. | 3′-氨基-3′-脱 ...
分享一篇发表在JACS上的文章。文章的题目是“3′-氨基-3′-脱氧核糖核苷的潜在前生物合成途径”。文章的通讯作者是来自University of Guelph化学系的Derek O'Flah ...
