分享一篇发表在Nature上的文章，题目为“Chemical capture of diazo metabolites reveals biosynthetic hydrazone oxidation ...
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原创知识
原创知识![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260215/1771121483161704.jpg)
原创知识Nature | 解锁调控CRBN功能的隐秘变构位点
分享一篇发表在Nature上的文章，题目为“Identification of an allosteric site on the E3 ligase adapter cereblon”。通讯作者分别 ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260213/1770964300701974.png)
原创知识Nat. Commun. | 序列和构象的联合优化实现蛋白质 ...
推荐一篇发布在Nature Communications上的文章，文章标题“Stable de novo protein design via joint conformational landsca ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260213/1770962993482691.jpg)
原创知识Nat. Chem. | “借力打力”：通过伪天然产物加速I ...
介绍一篇刚刚发表在Nature chemistry上的文章，题目为Monovalent pseudo-natural products supercharge degradation of IDO1 ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260211/1770793360372900.jpg)
原创知识Anal. Chem. | 化学发光驱动免疫荧光：高灵敏与长 ...
分享一篇发表在Analytical Chemistry上的文章，题目为Chemiluminescence-Driven Tyramide Amplification for High-Sensitiv ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260211/1770792859260909.jpg)
原创知识Cell Chem. Biol. | 绘制NCI-60细胞系 ...
分享一篇发表在Cell Chemical Biology上的文章，题目为“An interactive resource mapping the proteome and reactive cyste ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260208/1770516897108074.jpg)
原创知识J. Am. Chem. Soc. | 基于亲和色谱技术的分 ...
介绍一篇发表在J. Am. Chem. Soc.上的文章，题目为“Direct-to-Biology Enabled Molecular Glue Discovery”，通讯作者是圣裘德儿童研究医院的 ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260203/1770085674871043.jpg)
原创知识Anal. Chem. | 基于SuFEx的蛋白交联剂用于活 ...
分享一篇发表在Analytical Chemistry上的文章，题目为“Clickable Multitargeting Cross-Linkers Based on SuFEx for In Viv ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260202/1769996283922751.png)
原创知识TFA脱Boc后处理：从粗产物到纯品的关键净化之路
在三氟乙酸（TFA）作用下脱除叔丁氧羰基（Boc）保护基是多肽与有机合成中的常规操作。反应瞬间完成，但高效的后处理才是获得纯品、保证后续反应顺利进行的关键。这一过程的核心任 ...
![[value:title]](http://www.huaxuedingzhi.com/storage/12105/article/20260130/1769753405725484.jpg)
原创知识Nat. Biotechnol. | 抗体-凝集素嵌合体用于 ...
分享一篇发表在Nature Biotechnology上的文章，题目为“Antibody-lectin chimeras for glyco-immune checkpoint blockade”，通 ...
